Cannabis on Commercial Ave, right in the heart of the South Side.
Looking for a Chicago dispensary on the South Side? Mission South Chicago is here for you: stocked with Illinois cannabis products across every category, backed by a team of knowledgeable budtenders who genuinely love what they do.
We’re located on S Commercial Ave, easily accessible from I-90, I-94, and Lake Shore Drive, and convenient to South Side neighborhoods including Hyde Park, Kenwood, Avalon Park, and beyond. We offer free on-site parking, an ATM, ADA-accessible entry, and flexible payment options, including cash, debit, and Dutchie Pay-by-Bank.
Whether you’re an adult-use shopper or a registered Illinois medical patient, we’ve got a full menu ready for you. Stop in and let us help you find what you’re looking for.
Our South Chicago dispensary is always stocked with every cannabis product imaginable, from delicious edibles to potent concentrates and everything in between. If you need it, we’ve got it. And we don’t just sell Illinois’ favorite cannabis, we grow some of it, too.
If you haven’t tried Mission Cannabis, get ready for something worth discovering. Grown by a passionate team of cultivators, our cannabis delivers a pure expression of strain genetics in the form of fresh flower and quality pre-rolls. Check out our menu for a select strain list with a variety of THC levels to suit all tastes and needs.
Of course, that’s not all we offer. We proudly stock a wide selection of Illinois cannabis brands. Browse our online menus, or stop in and see what’s in stock today!
Mission has been serving the South Side since 2017, one of the first dispensaries to bring quality cannabis access to this community. Whether you’re shopping recreational or medical, you’ll find a thoughtfully stocked menu, a team that genuinely knows their products, and a dispensary experience built around making your visit easy and worthwhile.
New specials every day on top Illinois cannabis brands.
Expert guidance for every experience level and goal.
Cash, debit, or Dutchie Pay-by-Bank accepted.
Serving adult-use customers and registered IL medical patients.
Cannabis tinctures offer flexibility and precision. These liquid extracts can be taken sublingually or added to food and drink, making them an excellent choice for those seeking a low-profile option. Our range of tinctures in Chicago includes varying potencies and cannabinoid ratios to suit your goals.
When you pay with cash, there's no need to worry about any extra processing fees, and your transaction will remain completely anonymous.
We accept debit cards in addition to cash. Due to legal restrictions on cannabis, we cannot process credit card payments at this time.
A convenient debit-style payment system that’s quick, safe and secure. Set up an account today.
Short on time? Shop from anywhere and schedule a pickup that fits your schedule. Browse our recreational or medical menus, make your selections, and choose a convenient pickup time at checkout. Your order will be ready when you arrive.

Choose your products online for Mission South Chicago.

Pick your pickup time and payment method.

Bring your ID and payment; we'll have your order ready.
Great customer service, I placed an order online and went in to pick up, and Jazmin answered all my questions at the register for me to get a better deal. Great vibe inside
★★★★★
This place always has the friendliest staff and best range of products. I was helped by Erika on my last visit and she was so knowledgeable. Will definitely be returning.
★★★★★
Best dispensary around! Although ive ran into a small issue and was wondering if i could get a customer support email. Thanks!
★★★★★
Very welcoming atmosphere and friendly staff. melanie helped me out getting started with dabbing and getting all the tools I needed at a great price!
★★★★★
Always great people working here, Emmett & Greg are excellent in particular. They are friendly, helpful and always quick to offer me a good deal when available. I appreciate their hard work and friendly customer service. I will keep coming back, they’ve earned my patronage.
★★★★★
Quick answers for South Chicago shoppers.
We serve both adult-use customers and registered Illinois medical patients. Adult-use customers need a valid government-issued ID showing they’re 21 or older. Medical patients must be registered in Illinois’ Medical Cannabis Patient Program and should bring their IL MMJ card along with a valid ID.
Bring a valid, government-issued photo ID (21+) and your preferred payment method. We accept cash, debit, and Dutchie Pay-by-Bank, and there’s an ATM on-site if you need it. Medical patients should also bring their Illinois-issued MMJ card. We’re located at 8554 S Commercial Ave, Chicago, IL 60617.
Illinois residents may purchase up to 30g of flower, 5g of concentrate, or 500mg THC in edibles per visit. Out-of-state visitors are limited to half those amounts. Registered medical patients may purchase up to 2.5 oz (70.87g) every 14 days. See the full Illinois Cannabis Regulation and Tax Act for details.
Yes! Visitors 21+ with a valid government-issued ID can purchase recreational cannabis in Illinois. Out-of-state purchase limits are lower than for Illinois residents. See the Illinois Cannabis Regulation and Tax Act for specifics.
Yes! Browse our recreational or medical menus online, select your products, and choose pickup at checkout. We’ll have your order ready when you arrive. Just bring your ID and payment.
Our South Chicago dispensary is a convenient stop for shoppers from across the South Side, including Avalon Park, East Side, Englewood, Hyde Park, Kenwood, Jackson Park Highlands, Burbank, Chicago Ridge, and West Loop. We’re also conveniently located about 30 minutes from Chicago Midway Airport and 20 minutes from Downtown Chicago.
Near I-90 and I-94 on S Commercial Ave with free on-site parking.
Take S. Lake Shore Drive to E. Marquette Dr.
Continue onto S. South Shore Dr.
Continue onto S. Yates Blvd. Turn left onto S. Exchange St.
Continue onto S. Commercial Ave. to Mission South Chicago.
Take I-90 E to exit 105 for Anthony Ave toward 92 Rd St.
Turn right onto S Anthony Ave.
Turn right onto S Colfax Ave.
Turn left at the 1st cross street onto S South Chicago Ave.
Turn right onto S Essex Ave.
Turn right onto E 87th St.
Turn left onto S Commercial Ave. to Mission South Chicago.
Take I-94 to exit 61B toward 87th St.
Merge onto S Lafayette Ave.
Use the left 2 lanes to turn left onto W 87th St.
Turn left onto S Commercial Ave.
Browse Mission Cannabis and the Illinois brands we carry in South Chicago.
Mission South Chicago has been part of this community since 2017, and we’re proud to still be here serving the South Side every day. Whether you’re stopping in for your go-to products, exploring something new, or visiting as a medical patient, our team is ready to help.
Browse our recreational or medical menu, check out today’s deals, or just come say hello. We’ll be here.
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