Cannabis has a well-earned reputation for giving people the giggles, often transforming even the smallest moments into sources of uncontrollable laughter. As stress melts away and inhibitions take a back seat, it’s almost impossible not to crack a smile and find humor in life’s simplest quirks.
While all cannabis has the potential to lighten the mood, certain strains seem particularly gifted at unlocking fits of laughter and good vibes. Whether you’re looking to elevate your next comedy night or simply share some infectious chuckles with friends, these strains stand out for their ability to tickle your funny bone.
So, what strain has you laughing the hardest? Here’s our ultimate guide to the cannabis strains you must try if you’re all about chasing those joyful, laugh-filled moments.
What Strain Makes You Laugh The Most?
What’s the secret to a laugh-out-loud cannabis strain? For some, the question comes down to, “Does sativa or indica make you laugh?” But with all due respect to both major styles of cannabis, research suggests that it’s a given strain’s unique cannabinoid and terpene profile that has the most significant impact on our giggles.
You’re probably familiar with cannabinoids already—the family of compounds such as THC and CBD that interact with our body’s endocannabinoid system to produce the bulk of the plant’s psychoactive effects. THC helps modulate dopamine, a vital brain chemical that controls mood, among other functions, which may lead to relaxation, focus, and an overall sense of calm and well-being.
But don’t forget CBD—since it acts on our brain’s serotonin receptors, CBD can impart a natural mood-elevating effect on many consumers. Studies demonstrate that by reducing the production of the stress hormone cortisol, CBD may minimize stress as well. While neither of these actions guarantees laughter, you might agree that feeling calmer and less stressed can be a strong invitation for a light-hearted giggle-fit.
Do Terpenes Make Us Laugh?
What about terpenes, the aromatic compounds that give each strain its characteristic sensory qualities? It turns out that they’re contributing more than just pretty scents. Clinical research supports the notion that many of the most abundant terpenes found in cannabis may play a large role in modulating our experience of cannabis.
Limonene, for example, is known to help reduce stress and anxiety, while caryophyllene may deliver powerful analgesic and anti-anxiety properties, and myrcene may impart gentle sedative effects. Again, while none of these are precisely laugh-inducing, they’re all prerequisites for the kind of giggles that help us relax, bond, and blow off steam.
Weed that Makes You Laugh: Top 10 Giggly Strains
So, what strain makes you laugh the most? Though there’s no one-size-fits-all when it comes to cannabis strains and your individual body, there are some strains that have gone through the test of time and come out on top as the most popular cultivars to induce laughter. Here’s our list of the top 10 strains that may make you laugh—give them a try and see what works for you:
Laughing Buddha
Including Laughing Buddha in this list was a no-brainer. This award-winning 75/25 sativa-dominant strain produces a nice blend of mentally and physically uplifting effects for many cannabis fans. It has also been suggested for those seeking a boost of creativity.
Honeydew
A 70/30 sativa-dominant hybrid, Honeydew is named for its delicious melon-like flavor—but that’s not the only thing it brings to the table. Honeydew may leave you feeling happy and sociable for hours on end, so it can be a great option for enjoying with friends or as a personal pick-me-up during the day.
Durban Poison
While its name may sound intense, for many, Durban Poison produces some nice uplifting and mood-boosting effects that conjure up the giggles. This legendary sativa strain produces a happy head high that can sometimes feel energizing and may also make it one of the best strains for creativity.
Super Lemon Haze
Many partakers experience extra uplifting, energizing, and euphoric cerebral effects from Super Lemon Haze. Thanks to these stimulating effects, it’s known for its giddy, happy head buzz and as a bright daytime strain. Along with a boost of energy, you may also feel chatty and social, making Super Lemon Haze a go-to strain for sharing with friends.
Diesel
Diesel is an infamous strain whose genetics have spawned many other varieties, such as Sour Diesel and Blue Diesel. Many choose this 70/30 sativa for its invigorating effects and notable mental focus. Like Super Lemon Haze and Laughing Buddha, it’s also a fan favorite for sparking creativity.
Chronic
Some have described Chronis as effortless and unique. It’s a hybrid cross of Northern Lights and AK-47 that can deliver a balanced blend of uplifting, cerebral effects and a smooth, full-body high. Even better? If you’re into straight-up delicious weed, Chronic’s spicy, honey-scented aroma is truly something to behold.
Church OG
Though it may not make you see God, Church OG is beloved for helping tamp down chronic pain and imparting deep, full-body relaxation. Best of all, it can kickstart a serious case of the giggles. It’s not as energizing as most of the other strains on this list, but it can be an excellent option for gentle unwinding after a long day.
OG Kush
A true legend in the cannabis world, this highly potent strain may impart a powerful sense of bodily relaxation mixed with an energizing cerebral lift. These attributes make OG Kush a powerful tool for fighting stress, chronic pain, and other symptoms felt by many cannabis patients. Aside from the potential therapeutic benefits, it’s tough to top OG Kush for a happy, giggly, and sociable experience. Some creatives have also found that it can generate a special, creative spark to help them get in the zone.
Ice Cream Cake
If you’re ready to melt into total relaxation, this sweet, vanilla-scented strain may deliver a deep, full-body calm that often inspires deep belly laughs along the way. An indica-leaning cross between two blockbuster strains—Wedding Cake and Gelato #33—Ice Cream Cake is about dropping into your body, shedding stress, and getting ready for bed. If that also involves some intense giggles, all the better.
Ghost Train Haze
This heady sativa packages the giggles in an aromatic floral, citrus, and sour fruit blend. Though it’s a mouthwatering option, Ghost Train Haze can be somewhat dose-dependent—some fans report that it’s excellent for imparting a stimulating, creative buzz at low doses. But, have a little too much, and you could find yourself riding this train into a foggy haze.
Shop Mission To Get Your Giggle On
They say laughter is the best medicine—and cannabis can be the perfect shortcut to a fit of giggles. But instead of asking, “Does sativa or indica make you laugh?” the real question is, “Which terpenes spark the laughter”? These aromatic compounds define a strain’s scent and play a key role in influencing mood and enhancing your sense of well-being—which often translates to more laughter. When you’re ready to bring on the giggles, find your nearest Illinois or Massachusetts dispensary to get started!
Ready to explore more fun and fascinating strains? Check out our strain reviews featuring highlights like The Soap, Cheetah Piss, and other must-try favorites.
