What Strain Makes You Laugh The Most? Top 5 Giggly Strains

Cannabis has a reputation for giving people the giggles. As their worries are lifted and their inhibitions are carried away, some people just can’t help but crack a smile and break out into laughter, even at the smallest things.

Some strains certainly seem to be more capable of triggering fits of giggles and laughter than others. What strain makes you laugh the most? Here’s our guide to the cannabis strains you absolutely need to try if you love to laugh.

strain makes you laugh

What Strain Makes You Laugh The Most?

While there is no single strain that is known for making people laugh ‘the most’, it does seem that sativa strains are a better choice than indicas when it comes to making people laugh.

This might be explained by the fact that sativas are known for producing an uplifting cerebral high that tends to produce more mental effects rather than physical ones. As THC is metabolized, serotonin and dopamine–two mood-enhancing neurotransmitters–are released. Combining the cerebral effects of sativa strains with the mood boosting effect of these neurotransmitters may produce a powerful 1-2 punch that can have you laughing till your sides hurt.

So what strain makes you laugh the most? Here’s our list of the top 5 strains that make you laugh. Try them out yourself and let us know!

strain makes you laugh

Laughing Buddha

Adding this one to the list was a no-brainer. As you can probably tell by its name, Laughing Buddha is a weed that makes you laugh. This award-winning 75/25 sativa-dominant strain produces a nice blend of mentally and physically uplifting effects, and has also been suggested to those looking for strains for creativity.


This 70/30 sativa-dominant strain is named after its delicious melon-like flavor, but that’s not the only thing it brings to the table. Honeydew will have you feeling happy and sociable for hours and is great for enjoying with friends or as a personal pick-me-up during the day.

Durban Poison

While its name may sound pretty intense, Durban Poisonactually produces some nice uplifting and mood-boosting effects that can have you giggling in no time. This legendary sativa produces a happy head high that can sometimes feel energizing and may also make it one of the best strains for creativity. If you’re looking for weed that makes you laugh, make sure to give Durban Poison a try.

Super Lemon Haze

Super Lemon Hazetends to produce very uplifting, energizing, and euphoric cerebral effects. It’s known for its giddy and happy head buzz, and for being a great daytime strain thanks to its energizing effects. Along with a boost of energy you might also feel a sudden desire to be social, making Super Lemon Haze a great strain to share with friends so you can enjoy a solid group giggle fest.


Diesel is an infamous strain whose genetics have been used to spawn many other Diesel varieties like Sour Diesel and Blue Diesel. This 70/30 sativa produces an invigorating and energizing high that is perfect for socializing and sharing a laugh with friends. Diesel is also one of our favorite creative strains and it’s a great choice if you’re looking for something to give you a boost of focus, energy, and creativity.

strain makes you laugh

Find All Your Favorite Cannabis Strains At Mission

Looking to get your hands on some fun and uplifting strains to make you laugh? Come by one of our many locations or check out our online menu right now to browse a huge variety of cannabis flower buds and pre-rolls. We look forward to serving you!